Glyoxylic acid, the two functional groups of the aldehyde group and a carboxyl group in the molecule, which has the Properties of the aldehyde and a carboxylic acid having a variety of reactive. Glyoxylic acid has the structure of the aldehyde and acid, the chemical Properties quite lively, as an important organic intermediates, continues to expand in the field of pharmaceuticals, pesticides, spices. Glyoxylic acid is widely used in organic synthesis intermediates, spices, pharmaceuticals, pesticides, food, varnish raw materials, dyes, plastic additives can also be used for the production of oral penicillin, vanillin, ethyl vanillin, mandelic acid and allantoin and other products.

The most commonly used methods  in industry are oxalic acid electrolytic reduction, Glyoxal nitric acid oxidation method and maleic acid (anhydride) Ozonation.

Glyoxal nitric acid oxidation method: The method’s  reaction conditions is mild,  the process is simple and mature, less investment in equipment used by most manufacturers at home and abroad, but waste acid of the method separation difficulties, the purity of the product is low, the quality is poor. Nitric acid corrosion of equipment, the high concentration easy to appear bumping, unreacted finished nitric acid glyoxylate slow oxidative decomposition reaction of nitric oxide gas polluting the environment, the unconverted glyoxal interference glyoxylic acid condensation reaction, and limits the scope of its application. In the research work, the active method is using oxygen instead of nitric acid catalytic glyoxal prepared glyoxylate, commonly used catalysts are precious metals, nitrogen oxides, or a solid acid. However, in the trial production found that the activity and life of these catalysts is not ideal, and there is an urgent need for mass production of glyoxylic acid production catalyst.Bromine and a halide to form a stable complex, sodium bromate is ideal as a catalyst.

Oxalic acid electrolytic reduction method: This method is applicable to electric power is sufficient, adequate sources of raw oxalic geographical. This process technology is simple, easy to operate, under mild conditions, the current efficiency is also high, almost no byproducts, but the solution evaporation, and the purity of the product is also low, cathode easily inactivation. One of the disadvantages of the process is the anodic reaction for the electrolysis of water, did not create economic benefits. In order to improve the current efficiency and electrolyzer production capacity as well as improve the electrochemical synthesis of glyoxylic acid process of competitiveness, it is necessary to take full advantage of the anode reaction to produce chemical products, play a paired electrolysis advantage.

Maleic acid (anhydride) ozonation method: This method is up to 93% yield of the product, the quality is good, 100% of the conversion rate of maleic acid little pollution; large investment, high power consumption, harsh reaction conditions, byproductsformic acid corrosion of equipment, In addition ozone occurred and deal with the problem of inconvenience.

Glyoxylic acid is an important organic chemical raw materials and intermediates, mainly used for the production hydroxyphenylglycine and vanillin. Glyoxylic acid, expanding production scale, the environmental pollution problems of the existing process becomes increasingly pronounced, the researchers at home and abroad are working to develop the glyoxylic acid cleaner production processes.

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